KYZATREX®:
The Next Level in
Testosterone
Replacement Therapy (TRT)
[vc_column_text css=”” el_class=”light”]Offer patients a simple, painless way to manage low testosterone with twice-daily oral capsules.[/vc_column_text][vc_column_text css=”.vc_custom_1763068679696{padding-top: 15px !important;}” el_class=”light” font_weight=”400″]KYZATREX is helping patients ditch the painful injections and messy gels for an oral option that fits effortlessly into everyday life.[/vc_column_text] [/vc_column_inner][vc_column_inner width=”1/2″ css=”.vc_custom_1712751370572{margin-bottom: 0px !important;}”][vc_single_image image=”875″ el_class=”hero-image”][vc_column_text css=”” text_align=”right” color=”#ffffff”]Actor Portrayal[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1712751407735{padding-top: 200px !important;padding-bottom: 60px !important;background-image: url(http://backups.levoengage.com/wp-content/uploads/2024/04/why-kyza-mobile-hero.jpg?id=2875) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” min_height=”100vh” el_class=”Hero-main mobile-hero-section” visibility=”visible-phone” el_id=”mobile-swap” wpex_bg_position=”top center”][vc_column][vc_row_inner][vc_column_inner el_class=”hero-col-1″ width=”1/2″][vc_column_text css=”.vc_custom_1722537473969{padding-bottom: 15px !important;}” text_align=”right” color=”#ffffff”]Actor Portrayal[/vc_column_text][vc_column_text el_class=”light”]Simplifying Testosterone Treatment[/vc_column_text]KYZATREX®:
The Next Level in
Testosterone
Replacement Therapy (TRT)
[vc_column_text el_class=”light”]Offer patients a simple, painless way to manage low testosterone with twice-daily oral capsules.[/vc_column_text][vc_column_text css=”.vc_custom_1711648109438{padding-top: 15px !important;}” el_class=”light” font_weight=”400″]KYZATREX is helping patients ditch the painful injections and messy gels for an oral option that fits effortlessly into everyday life.[/vc_column_text] [/vc_column_inner][vc_column_inner width=”1/2″][vc_single_image image=”875″ el_class=”hero-image”][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1712694409107{padding-top: 80px !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” wpex_bg_position=”top”][vc_column][vc_row_inner el_class=”max-width-1400″ el_id=”second-row-inner”][vc_column_inner width=”1/3″][vc_single_image image=”5496″ css=””][/vc_column_inner][vc_column_inner width=”1/3″][vc_single_image image=”5497″ css=””][/vc_column_inner][vc_column_inner width=”1/3″][vc_single_image image=”5498″ css=””][/vc_column_inner][/vc_row_inner][vc_row_inner el_class=”max-width-1400″ css=”.vc_custom_1709132788245{margin-top: 0px !important;}”][vc_column_inner][vc_column_text css=”.vc_custom_1763069155735{padding-top: 10px !important;padding-right: 10px !important;padding-bottom: 10px !important;padding-left: 10px !important;background-color: #dcebf7 !important;border-radius: 10px !important;}” text_align=”center” line_height=”18.2px” font_weight=”400″ el_class=”primary-dark body-sm”]*In a six-month open-label clinical study (n=139) of men with low testosterone, 88% achieved Cavg 222-800 ng/dL at Day 90 (worst case scenario calculation, Investigator Site 104, 95% CI, 82% to 93%).Based on end-of-study completers (n=127), 96% of patients achieved Cavg 222-800 ng/dL at Day 90 (95% CI, 93 to 99%).[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1712820089987{margin-bottom: 20px !important;}”][vc_column]
KYZATREX is Optimized for Lymphatic Uptake
[vc_column_text css=”” el_class=”center-txt primary-dark”]KYZATREX utilizes a Self-Emulsifying Drug Delivery System (SEDDS) enhanced with phytosterol esters to route testosterone undecanoate (TU) through the intestinal lymphatic system, bypassing the liver and avoiding first-pass metabolism.1,2[/vc_column_text][/vc_column][/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column][vc_row_inner el_class=”max-width-1400″][vc_column_inner][vc_video link=”https://vimeo.com/1125955292″ align=”center” css=”” el_class=”max-width-1400″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row”][vc_column][vc_row_inner el_class=”max-width-1400 fifth-inner-wraper-mobile” css=”.vc_custom_1709234113029{padding-top: 0px !important;padding-bottom: 0px !important;}”][vc_column_inner width=”1/4″][/vc_column_inner][vc_column_inner width=”1/2″ css=”.vc_custom_1711651255967{margin-bottom: 20px !important;}”]A Broad PK Profile Without Extreme Peaks and Troughs1,3,4
[vc_column_text css=”” el_class=”primary-dark center-txt”]KYZATREX is designed to restore and maintain testosterone levels in aphysiologic pattern following each dose.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][/vc_column_inner][/vc_row_inner][vc_row_inner el_class=”max-width-1400″][vc_column_inner]
Mean Concentration-Time Profile (N=139)
[vc_single_image image=”5504″ alignment=”center” css=””][vc_column_text css=”.vc_custom_1763664340997{margin-top: 50px !important;}” el_class=”primary-dark center-txt”]Mean (Standard Error of the Mean) Testosterone Concentration (ng/dL) Post Morning KYZATREX Dose at Day 90. KYZATREX safely restores T levels while allowing the hypothalamic-pituitary-gonadal (HPG) axis to remain active. T levels return to near baseline between KYZATREX doses, maintaining HPG axis function.3[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1712854760795{border-top-width: 100px !important;background-color: #eef5f9 !important;}” el_class=”proven_to_boost_row”][vc_column][vc_row_inner content_placement=”middle” el_class=”small_container_1170 six-row-inner-wraper”][vc_column_inner]Clinically Restore Testosterone Levels
[vc_column_text css=”” el_class=”primary-dark center-txt”]The efficacy of KYZATREX was evaluated in a 6-month open-label clinical study involving 139 hypogonadal men (median age of 50 years; range 22 to 66 years). The primary efficacy endpoint was the percentage of KYZATREX-treated patients with mean plasma total testosterone concentration (Cavg) over 24-hours within the normal range of 222-800 ng/dl on the final PK visit of the study at Day 90.KYZATREX demonstrated the following at Day 90:[/vc_column_text][/vc_column_inner][/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”middle” gap=”30″ el_class=”small_container_1170 six-row-inner-wraper2″][vc_column_inner el_class=”remove_col_bottom_margin_mobile” width=”1/3″ css=”.vc_custom_1763147661095{padding-top: 20px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: rgba(88,154,199,0.1) !important;*background-color: rgb(88,154,199) !important;}”]
[/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1712855069385{border-top-width: 100px !important;}” el_class=”proven_to_boost_row”][vc_column][vc_row_inner el_class=”max-width-1400″][vc_column_inner css=”.vc_custom_1711656030938{margin-bottom: 20px !important;}”]
Demonstrated Safety Profile
[/vc_column_inner][/vc_row_inner][vc_row_inner equal_height=”yes” gap=”30″ el_class=”small_container_1170″][vc_column_inner el_class=”card-inner-wraper remove_col_bottom_margin_mobile” width=”1/2″ css=”.vc_custom_1712090794419{padding-top: 60px !important;padding-right: 60px !important;padding-bottom: 60px !important;padding-left: 60px !important;background-color: #eef5f9 !important;}”]
No patients discontinued due to erythrocytosis.1,3[/vc_column_text][vc_column_text css=”” el_class=”fw-400 primary-dark body-sm center-txt”]In a 12-month, open-label clinical study, men who received KYZATREX 200 mg QD to 400 mg BID (n = 202) reported the following additional adverse reactions: headache, arthralgia, diarrhea, hemoglobin increased, anxiety, constipation, peripheral edema, and prostate-specific antigen increased.3[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” remove_bottom_col_margin=”true” css=”.vc_custom_1763146792258{padding-top: 80px !important;padding-bottom: 90px !important;background-color: rgba(88,154,199,0.1) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;*background-color: rgb(88,154,199) !important;}” wpex_zindex=”2″][vc_column css_animation=”none” el_class=”section-section-wraper” css=”.vc_custom_1711640484999{margin-bottom: 0px !important;}”][vc_row_inner el_class=”small-width-container”][vc_column_inner]
Provider and Patient Preference for Oral Testosterone6
[/vc_column_inner][/vc_row_inner][vc_row_inner equal_height=”yes” gap=”30″][vc_column_inner el_class=”remove_col_bottom_margin_mobile” width=”1/2″ css=”.vc_custom_1712070612957{padding-top: 30px !important;padding-right: 20px !important;padding-bottom: 30px !important;padding-left: 20px !important;background-color: #dcebf7 !important;}”]It’s All in the Delivery
KYZATREX Daily Oral Dosing
[vc_column_text css=”” font_weight=”400″ el_class=”primary-dark center-txt”]Testosterone-boosting benefits taken twice a day with food3[/vc_column_text][/vc_column_inner][/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”middle” css=”.vc_custom_1763147236048{padding-top: 40px !important;padding-right: 40px !important;padding-left: 40px !important;background-color: #ffffff !important;}” el_class=”small_container_1170 padding_sides”][vc_column_inner el_class=”mobile-padding-20″ width=”1/2″][vc_column_text css=”” el_class=”fw-400 primary-dark”]Dosing Flexibility
Meet your patient’s testosterone needs with a range of
KYZATREX doses.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][vc_single_image image=”5508″ alignment=”center” css=””][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1712610136602{padding-top: 80px !important;}”][vc_column css=”.vc_custom_1711657644125{margin-bottom: 0px !important;}”][vc_row_inner el_class=”max-width-1400″][vc_column_inner][vc_column_text css=”” el_class=”primary-dark body-sm”]References:
- Bernstein JS. Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024;16:1-17. doi: 10.177/17562872241241864
- Kanabur P, Brunner R, Khera D, et al. The Evolving Role of Novel Oral Agents for Testosterone Replacement Therapy; A Historical Perspective. Adrog Clin Res Ther. 2022;3.1:224-232. doi: 10.1089/andro.2021.0025
- KYZATREX [prescribing information]. Raleigh, NC: Marius Pharmaceuticals; 2025.
- Data on file. Raleigh, NC: Marius Pharmaceuticals, 2020.
- Krakowsky Y, Grober E. Testosterone deficiency – Establishing a Biochemical Diagnosis. EJIFCC. 2015 Mar; 26(2): 105–113.PMID: 27683486; PMCID: PMC4975356.
- Data on file. Raleigh, NC: Marius Pharmaceuticals, 2018.